PF-1355

SKU: orb1304131

Description

PF-1355

Research Area

Product Categories/Products/Small Molecules,Metabolism

Key Properties

• CAS Number: 1435467-38-1
• MW: 321.35
• Purity: 99.77%
• Formula: C₁₄H₁₅N₃O₄S
• SMILES: O=C1C=C(C=2C=C(OC)C=CC2OC)N(C(=S)N1)CC(=O)N

Bioactivity

• In Vivo:
  Administering PF-1355 orally diminishes MPO activity in plasma, lessens vascular edema and neutrophil recruitment, and increases circulating cytokines levels. PF-1355 treatment entirely inhibits albuminuria and chronic renal dysfunction in a model of anti-glomerular basement membrane disease .
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• In Vitro:
  PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71568997