A-674563 2HCl(552325-73-2(fb-2hcl))

SKU: orb1219449

Description

A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and > 30-fold selective for Akt1 over PKC.A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro (EC50: 0.4 μM) [1]. A563 (0-10 μM) markedly decreases GSK3 and MDM2 phosphorylation in STS cells.

Research Area

,Product Categories/Small Molecules

Images & Validation

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Key Properties

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CAS Number	——
MW	431.4
Purity	> 98% (HPLC)
Formula	C₂₂H₂₄Cl₂N₄O
Target	Akt1\|CDK2\|PKA\|ERK2\|PKCδ

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Akt1|CDK2|PKA|ERK2|PKCδ

Protocol Information

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