Anti-Hu CD368 APC

SKU: orb1742784

Description

CD368 is an approximately 25-30 kDa C-type lectin, which serves as one of pattern recognition receptors of the innate immune system. It recognizes pathogen-associated molecular patterns of bacteria and fungi, such as alpha-mannans or trehalose 6,6´-dimycolate, and transfers the signal downstream using associated Fc receptor gamma chain. CD368 is expressed on neutrophils, monocytes, and on some populations of blood dendritic cells, but it decreases during differentiation of monocytes into dendritic cells or macrophages. Increased expression can be induced by IFN-gamma, TNF-alpha, IL-6, and IL-10. CD368 triggering leads to driving of antigen-presenting cells maturation and to promotion of T cell differentiation into Th1 and Th17.

Images & Validation

• Tested Applications: FC
• Reactivity: Human, Primate
• Application Notes:
  Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Key Properties

• Clonality: Monoclonal
• Isotype: Mouse IgG2b kappa
• Clone No.: 9B9
• Immunogen: CD368 ectodomain fused with human Fc
• Target: CD368
• Conjugation: APC

Storage & Handling

• Storage: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
• Buffer/Preservatives: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CLEC6, CLEC4D, dectin 3, MCL, MPCL

Quick Database Links

Gene Symbol

CD368

UniProt

Q8WXI8

NCBI Gene ID

338339