Anti-Hu CX3CR1 FITC

SKU: orb2704157

Description

CX3CR1 (fractalkine receptor) serves as a regulator of leukocyte trafficking. Its ligand CX3CL1 (fractalkine) can serve bots as chemoatractant (soluble) and as adhesive molecule (membrane bound). Binding to the cell surface expressed ligand leads to rapid induction of firm adhesion of CX3CR1-positive cells without requiring selectin-mediated rolling or activation of integrins. This interaction is important for trafficking of cytotoxic effector lymphocytes regardless of their lineage and mode of target cell recognition, through inflamed endothelium. Similarly, it mediates monocyte/macrophage recruitment to inflamed atherosclerotic plaques, as well as in their homing to non-inflamed tissues, where they can differentiate into dendritic cells. CX3CR1 also promotes cell survival, plays a key role in brain microglia, synapse maturation and regulation of inflammatory response in the central nervous system, it acts as a negative regulator of angiogenesis, and serves as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi.

Images & Validation

• Tested Applications: FC
• Reactivity: Human, Primate
• Application Notes:
  Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Key Properties

• Clonality: Monoclonal
• Isotype: Rat IgG2b kappa
• Clone No.: 2A9-1
• Immunogen: human CX3CR1 transfectants
• Target: CX3CR1
• Conjugation: FITC

Storage & Handling

• Storage: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
• Buffer/Preservatives: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1, fractalkine receptor

Quick Database Links

Gene Symbol

CX3CR1

UniProt

P49238

NCBI Gene ID

1524