AP24534 hydrochloride

SKU: orb2703372

Description

Ponatinib, also known as AP24534 is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib. Ponatinib has been designed to be effective against these types of tumors. Ponatinib was approved in 2012.

Key Properties

• CAS Number: [1114544-31-8]
• MW: 569.02
• Formula: C₂₉H₂₈CLF₃N₆O
• SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only