IACS-13909

SKU: orb746463

Description

IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses the signaling of RTK/MAPK pathway and overcomes multiple mechanisms underlying osimertinib resistance. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to osimertinib, IACS-13909 administered as a single agent or in combination with osimertinib potently reduces tumor cell proliferation in vitro and in vivo. Together, our findings provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [2160546-07-4]
• MW: 377.27
• Formula: C₁₇H₁₈Cl₂N₆
• SMILES: ClC1C(Cl)=C(C2C3N=CC(=NC=3NN=2)N2CCC(N)(C)CC2)C=CC=1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only