KSQ-4279 (Synonyms: USP1-IN-1)

SKU: orb2279864

Description

KSQ-4279 is a USP1 and PARP inhibitor. KSQ-4279 showed anti-proliferative effects in a subset of cell lines, often characterized by the presence of homologous recombination deficiencies (HRD), including mutations in BRCA1/2. The combination of KSQ-4279 with olaparib was able to induce strong and durable regressions across a number of ovarian and TNBC PDX models.

Key Properties

• CAS Number: [2446480-97-1]
• MW: 534.54
• Formula: C₂₇H₂₅F₃N₈O
• SMILES: C1(C2=C(OC)N=CN=C2C2CC2)=NC=C2C=NN(CC3=CC=C(C4N(C(C)C)C=C(C(F)(F)F)N=4)C=C3)C2=N1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only