PEG2000-C-DMG

SKU: orb1568326

Description

PEG(2000)-C-DMG represents a PEGylated derivative synthesized from 1,2-dimyristoyl-sn-glycerol (1,2-DMG). This compound is instrumental in the formulation of lipid nanoparticles (LNPs), particularly when combined with other lipidic compounds, for the efficient delivery of small interfering RNA (siRNA). Specifically, LNPs incorporating PEG(2000)-C-DMG and encapsulating siRNA designed to target the genes responsible for encoding programmed cell death protein ligand 1 (PD-L1) and PD-L2 have demonstrated efficacy in reducing the expression levels of PD-L1 and PD-L2 in monocyte-derived dendritic cells. Furthermore, formulations that include PEG(2000)-C-DMG are being actively explored in the advancement of LNPs aimed at the delivery of siRNA-based vaccines, highlighting its critical role in the development of therapeutic and prophylactic strategies.

Research Area

Product Categories/Products/Small Molecules

Key Properties

• CAS Number: [1019000-64-6]
• Purity: > 98%
• Formula: C₃₆H₇₃NO₅(C₂H₄O)N
• SMILES: CCCCCCCCCCCCCCOCC(OCCCCCCCCCCCCCC)COC(=O)NCCCO{-}CC{+n}OC

Storage & Handling

• Storage: 2 years in -20°C Powder, 2 weeks in 4°C in DMSO, 6 months in -80°C in DMSO
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only