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PROTAC SMARCA2/4-degrader-17

SKU: orb2664181

Description

PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It degrades SMARCA2 in A549 cells with a DC50<100 nM and SMARCA4 in MV411 cells, also demonstrating a DC50<100 nM.

Images & Validation

Key Properties

CAS Number2568276-88-8
MW936.13
Purity98.00%
FormulaC51H57N11O5S
SMILESNC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5=C(C)C=C(CC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)C=C5)C=C(N=N1)C9=C(O)C=CC=C9

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information