SB02024

SKU: orb1146672

Description

SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, > 1000 times selective towards other PI3K isoenzymes; SB02024 is also highly selective at 1 uM in the DiscoveRx ScanMax panel of 468 kinases; reduces the number of GFP-2xFYVE puncta with IC50 of 14 nM, induces a dose-dependent increase in levels of NCOA4 and p62; blocks autophagy in vitro and reduces xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7; also significantly potentiates cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro.

Research Area

Product Categories/Products/Small Molecules

Key Properties

• CAS Number: [2126737-28-6]
• MW: 345.36
• Formula: C₁₆H₂₂F₃N₃O₂
• SMILES: O=C1NC(N2[C@@H](C(F)(F)F)CCCC2)=CC(N3[C@H](C)COCC3)=C1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Hazard Information: Non-Toxic
• Disclaimer: For research use only