Shepherdin TFA

SKU: orb1980030

Description

Shepherdin is a synthetic peptide mirroring amino acids 79-87 of human survivin, acting as an inhibitor of the survivin-heat shock protein 90 (Hsp90) interaction. It specifically targets the N-terminal domain of Hsp90, blocking the survivin-Hsp90 interaction in human reticulocyte extracts at a 150 µM concentration. Conjugates of Shepherdin with cell-permeable peptides, such as penetratin or the HIV Tat sequence, exhibit anticancer properties both in vitro and in vivo.

Key Properties

• MW: 949.10
• Purity: 98.00%
• Formula: C₄₁H₆₄N₁₂O₁₂S.XCF₃COOH
• SMILES: O=C(N[C@H](C(O)=O)CC(C)C)[C@@H](NC([C@H](C)NC([C@H](CS)NC(CNC([C@H](CO)NC([C@H](CO)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC1=CN=CN1)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2.OC(C(F)(F)F)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168355588