YCH1899

SKU: orb2277778

Description

YCH1899, an orally active PARP inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM. It shows marked antiproliferative efficacy against Olaparib-resistant (Capan-1/OP) and Talazoparib-resistant (Capan-1/TP) cells with IC50 values of 0.89 nM and 1.13 nM, respectively. Moreover, YCH1899 possesses favorable pharmacokinetic attributes in rats [1].

Research Area

,Chromatin/Epigenetic|||DNA Damage/DNA Repair

Key Properties

• MW: 549.35
• Purity: 98.00%
• Formula: C₂₅H₁₈BrFN₆O₃

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only