ACE2 Antibody / Angiotensin-Converting Enzyme 2

SKU: orb1822585

Description

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Images & Validation

• Tested Applications: ELISA, IHC-P
• Dilution Range: ELISA (Order BSA-free format for coating),Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Recombinant
• Isotype: Rabbit IgG, kappa
• Clone No.: ACE2/8748R
• Immunogen: A recombinant partial protein sequence (within amino acids 705-805) from the human protein was used as the immunogen for the Angiotensin Converting Enzyme 2 antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the Angiotensin Converting Enzyme 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This Angiotensin Converting Enzyme 2 antibody is available for research use only.
• Disclaimer: For research use only

IHC staining of FFPE human small intestine tissue with Angiotensin Converting Enzyme 2 antibody (clone ACE2/8748R) at 2 ug/ml. HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

SDS-PAGE analysis of purified, BSA-free Angiotensin Converting Enzyme 2 antibody (clone ACE2/8748R) as confirmation of integrity and purity.

Quick Database Links

UniProt

Q9BYF1