Adarotene

SKU: orb1308690

Description

Adarotene

Research Area

Product Categories/Products/Small Molecules,Apoptosis

Key Properties

• CAS Number: 496868-77-0
• MW: 374.47
• Purity: 99.68%
• Formula: C₂₅H₂₆O₃
• SMILES: OC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2

Bioactivity

• In Vivo:
  Adarotene, administered orally at doses of 30 and 40 mg/kg, significantly extends the lifespan of NB4-bearing SCID mice in a dose-dependent manner without apparent toxicity . At lower doses of 15 and 20 mg/kg, it markedly inhibits tumor growth in human ovarian carcinoma (A2780/DX) and human melanoma (MeWo) models in nude mice .
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• In Vitro:
  Adarotene causes cell accumulation in the G1/S or S phase of the cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene causes dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM . Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. Adarotene treatment of cells results in rapid accumulation of intracellular calcium .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

9864378