ADCY8 Antibody / Adenylyl cyclase 8

SKU: orb1822945

Description

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

Images & Validation

• Tested Applications: IHC-P
• Dilution Range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG, kappa
• Clone No.: ADCY8/7341
• Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the Adenylyl cyclase 8 antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the Adenylyl cyclase 8ADCY8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This Adenylyl cyclase 8 antibody is available for research use only.
• Disclaimer: For research use only

SDS-PAGE analysis of purified, BSA-free Adenylyl cyclase 8 antibody (clone ADCY8/7341) as confirmation of integrity and purity.

IHC staining of FFPE human kidney tissue with Adenylyl cyclase 8 antibody (clone ADCY8/7341). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

IHC staining of FFPE human brain tissue with Adenylyl cyclase 8 antibody (clone ADCY8/7341). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

Quick Database Links

UniProt

P40145