Adenovirus Monoclonal Antibody

SKU: orb1921797

Description

Adenoviruses (AdVs) are non-enveloped icosahedral viruses with a double-stranded DNA genome. Hexon is one of the three major structural proteins of the adenovirus capsid, whose hypervariable regions exhibit the sequence variability among adenovirus serotypes. Hexon is the most abundant structural proteins, with 240 copies of the trimeric molecule in the capsid, accounting for approximately 60% of the total protein mass. Hexon is a large polypeptide, more than 900 amino acids long in all known adenovirus types. The monomer folds as two eight-stranded β barrels, or jellyroll domains, held apart by a small β-sheet. The double jelly rolls form the pseudo-hexagonal base of the trimeric hexon capsomer. Long loops intercalated between the β-strands form the hexon towers, and contain the hyper variable regions (HVRs). The N-termini and C-termini adopt different conformations depending on their location in the capsid, to establish interactions between hexons and minor coat proteins IIIa and VIII. The architecture of hexon is highly conserved throughout the Adenoviridae family. The main differences reside in the HVRs, which present a varying degree of flexibility in the different virus types.

Research Area

,Adenovirus

Images & Validation

• Tested Applications: CLIA, LF
• Application Notes:
  Recommended Applications: LFIA , CLIA. Test Methods: Self-produced antigen test; Test 10 Positive Reference Materials; Test Sample Extraction Solution, Test 10 normal Nasal Swab Samples; Test Covid-19, Influenza A/B & RSV controls

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Molecular Weight: 150 kDa
• Purity: > 95% pure (SDS-PAGE).
• Conjugation: Unconjugated

Storage & Handling

• Storage: For long term storage, the product should be stored at -20°C or lower.
• Form/Appearance: Purified,Liquid
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AdV-mAb