AICAR phosphate

SKU: orb1707700

Description

AICAR phosphate

Research Area

Product Categories/Products/Small Molecules,Autophagy|||PI3K/Akt/mTOR signaling|||Immunology/Inflammation|||Stem Cells|||Chromatin/Epigenetic

Key Properties

• CAS Number: 681006-28-0
• Purity: 100.00%
• Formula: C₉H₁₄N₄O₅.xH₃O₄P
• SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(N)=C(C(N)=O)N=C2.P(=O)(O)(O)O xH3O4P

Bioactivity

• In Vivo:
  Male 5-week-old ZDF rats were either subcutaneously injected with a single dose of AICAR phosphate (0.5 mg/g) or subjected to a single bout of treadmill running. The results showed that compared to untreated control ZDF rats, both the exercise group and the rats receiving AICAR phosphate injection exhibited significantly increased AMPK-α2 activity in the white gastrocnemius muscle.
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• In Vitro:
  HepG2 cells were treated with different concentrations of AICAR phosphate (0.1-1.0 mM) for 12, 24, and 48 hours, respectively. The final results demonstrated that AICAR phosphate reduced the expression of the insulin receptor protein.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

67675098