AIFM1 (C) Antibody, Rabbit Polyclonal

SKU: orb131804

Description

Rabbit polyclonal to AIFM1. Apoptosis-inducing factor 1, mitochondrial (AIFM1) belongs to the FAD-dependent oxidoreductase family. AIFM1 is a probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. AIFM1 also plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. AIFM1 binds to DNA in a sequence-independent manner.

Research Area

Product Categories/Products/Antibodies,Epigenetics,Cancer,Signaling Pathways,Product Categories/Research Area,Signaling Pathways/Apoptotic,Neuroscience

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Human
• Application Notes:
  < strong>WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; < br>< strong>Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human AIFM1.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human AIFM1
• Molecular Weight: 67
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Concentration: 100 μg/ml BSA
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti Apoptosis-inducing factor 1 antibody, anti mitochondrial antibody, anti Programmed cell death protein 8 antibody, anti AIF antibody, anti PDCD8 antibody

Quick Database Links

UniProt

O95831