AJ-97166

SKU: orb377554

Description

BIO-013077-01 is a pyrazole TGF-β inhibitor[1].A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies[1].

Research Area

Product Categories/Products/Small Molecules

Key Properties

• CAS Number: [746667-48-1]
• MW: 287.32
• Formula: C₁₇H₁₃N₅
• SMILES: CN1C(=O)CNN(C1=O)CCCCN2CCN(CC2)C3=NC=CC=N3

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only