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Alpha Synuclein A53T Mutant Pre-formed Fibrils (Type 1)
SKU: orb1822360
Featured
Description
Research Area
,Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein | Neuroscience | Neurodegeneration | Multiple System Atrophy
Images & Validation
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Item 1 of 8
| Tested Applications | In vitro, In vivo, SDS-PAGE, WB |
|---|---|
| Application Notes |
Key Properties
−| Source | Recombinant |
|---|---|
| Expression System | E. coli |
| Biological Activity | 100 µM A53T alpha synuclein protein monomer (SPR-325) seeded with 10 uM A53T alpha synuclein protein PFF (SPR-326) in 25 µM Thioflavin T (PBS pH 7.4, 100 µl reaction volume) generated a fluorescence intensity of 28 000 Relative Fluorescence Units after incubation at 37°C with shaking at 600 rpm for 56 hours. Fluorescence was measured by excitation at 450 nm and emission at 485 nm on a Molecular Devices Gemini XPS microplate reader. |
| Target | Alpha Synuclein A53T Mutant |
| Reactivity | Human |
| Tag | No tag |
| Protein Length | Full Length |
| MW | ~14.46 kDa |
| Purity | > 95% |
| Protein Sequence | MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA |
Storage & Handling
−| Storage | -80°C |
|---|---|
| Buffer/Preservatives | PBS pH 7.4 |
| Concentration | 2 mg/ml |
| Expiration Date | 6 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
−A53T mutant alpha synuclein, A53T mutated SNCA, A53T Alpha synuclein PFFs, Alpha synuclein PFF, Ala53thr mutant alpha synuclein, Alpha synuclein pre-formed fibrils, Alpha synuclein aggregates, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson disease familial 1 Protein
Quality Guarantee
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Quick Database Links
Gene Symbol
Alpha Synuclein A53T Mutant
UniProt
UniProt Details
− No UniProt data available
Protocol Information
Protein Handling and Storage Guide
Protein Handling Guide
WB
Western Blot (IB, immunoblot)
SDS-PAGE
Sodium Dodecyl Sulphate PolyAcrylamide Gel Electrophoresis
Available Sizes
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Usually dispatched within 2-3 weeks