Alpha Synuclein Pre-formed Fibrils (Type 2)

SKU: orb1822369

Description

Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2)

Research Area

,Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein | Neuroscience | Neurodegeneration | Multiple System Atrophy

Images & Validation

• Tested Applications: In vitro, In vivo, SDS-PAGE, WB
• Application Notes:
  Certified 95% pure using SDS-PAGE analysis. Made with low endotoxin monomer.

Key Properties

• Source: Recombinant
• Expression System: E. coli
• Biological Activity: Does not induce Lewy body inclusion formation in Sprague-Dawley rat primary hippocampal neurons. Thioflavin T emission curve shows only a small increase in fluorescence (indicative of alpha synuclein aggregation) when Type 2 alpha synuclein PFFs (SPR-317) are combined with alpha synuclein monomers (SPR-321 or SPR-316). Certain biological activities in other neuronal cells cannot be ruled out. Researchers should test compatibility prior to use.
• Target: Alpha Synuclein
• Reactivity: Human
• Tag: No tag
• Protein Length: Full Length
• MW: ~14.46 kDa
• Purity: > 95%
• Protein Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Storage & Handling

• Storage: -80°C
• Buffer/Preservatives: PBS pH 7.4
• Concentration: 2 mg/ml
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alpha synuclein PFFs, Alpha synuclein PFF, Alpha synuclein aggregates, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson disease familial 1 Protein

Quick Database Links

Gene Symbol

Alpha Synuclein

UniProt

P37840