Ampicillin sodium

SKU: orb1300814

Description

Ampicillin sodium

Research Area

Product Categories/Products/Small Molecules,Microbiology/Virology

Key Properties

• CAS Number: 69-52-3
• MW: 371.39
• Purity: 99.87%
• Formula: C₁₆H₁₈N₃NaO₄S
• SMILES: [Na+].CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C([O-])=O

Bioactivity

• Target IC50:
  HEK293 cells:> 100 μM (CC50)|transporter:9.9 mM (Ki)|carnitine/carnitine antiport:7.6 mM|enzyme transpeptidase:1.8 µg/mL
• In Vivo:
  METHODS: To study the antibacterial effect of Ampicillin sodium, Ampicillin (0.2 mL/20 g) was orally or subcutaneously injected into mice. RESULTS: The efficacy of Ampicillin in treating most infections is significantly better than that of Epicillin and Amoxycillin. METHODS: To study the neuroprotective effect of Ampicillin sodium, Ampicillin sodium (200 mg/kg) was intraperitoneally injected into a mouse model of transient anterior cerebral ischemia. RESULTS: Ampicillin sodium can significantly reduce hippocampal cell death, lower the activity of matrix metalloproteinases (MMP), and increase the expression of glutamate transporter-1 (GLT-1).
• In Vitro:
  METHODS: After treating porcine Escherichia coli with Ampicillin sodium (0.1, 1, 2.5, 5, 10 μg/mL), E.M.B was observed. The number of viable Escherichia coli on the culture medium. RESULTS: Ampicillin inhibited the growth of porcine Escherichia coli in a dose-dependent manner. The effective inhibitory concentration of Ampicillin is 2.5 μg/mL.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

23689391