Anti-EGFR [Matuzumab]

SKU: orb348869

Description

Human monoclonal antibody to EGFR

Research Area

Infectious Diseases,Product Categories/Products/Antibodies,Developmental Biology,Product Categories/Research Area,Epigenetics,Product Categories/Antibodies,Cancer,tumor marker; biosimilar; immunotherapy; cancer; oncology; tumor; glioma

Images & Validation

• Tested Applications: Blocking, ELISA, FC, IF, WB
• Reactivity: Human

Key Properties

• Host: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone No.: Matuzumab
• Immunogen: The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.
• Target: EGFR
• Purity: Purified
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ErbB-1; ERBB1; HER1; EGF; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EMD72000; mAb425; 425; mAb 425

Quick Database Links

Gene Symbol

EGFR

UniProt

P00533

Murthy, U. et al. Binding of an antagonistic monoclonal antibody to an intact and fragmented EGF-receptor polypeptide Arch Biochem Biophys, 252, 549-560 (1987)

PubMed: 2434025

Reactivity

Human