Anti-FOLR1 / FRA Reference Antibody (mirvetuximab)

SKU: orb1818373

Description

Recombinant Antibody

Images & Validation

• Tested Applications: ELISA, FC
• Reactivity: Human, Mouse, Rat

Key Properties

• Antibody Type: Primary Antibody
• Clonality: Monoclonal
• Isotype: IgG1
• Source/Expression System: CHO Cell
• Protein Sequence: FOLR1 / FRA
• Molecular Weight: 150 Da
• Endotoxin: < 0.001EU/μg,determined by LAL method.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified monoclonal antibody supplied in PBS, pH 6.0, without preservative.This antibody is purified through a protein A column.
• Concentration: 1mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Folate receptor alpha, FR-alpha, Adult folate-binding protein, FBP, Folate receptor 1, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18, FOLR1, FOLR

The purity of Anti-FOLR1 / FRA Reference Antibody (mirvetuximab) is more than 100%, determined by SEC-HPLC.

Immobilized human FRa His at 2 µg/mL can bind Anti-FOLR1 / FRA Reference Antibody (mirvetuximab), EC50=0.01123 µg/mL

Anti-FOLR1 / FRA Reference Antibody (mirvetuximab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%

The endocytosis ratio mirvetuximab by Human Frα HEK 293 increased with the increase of antibody concentration, and the Internalization Rate (%) 75% at antibody concentration of 55 ng/mL.

SKOV3 cells were stained with Anti-FOLR1 / FRA Reference Antibody (mirvetuximab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC168=0.03238 ug/mL

Quick Database Links

UniProt

P15328