Anti-FOLR1 Reference Antibody (mirvetuximab)

SKU: orb1806347

Description

Anti-FOLR1 Reference Antibody is expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.2 kDa.

Images & Validation

• Tested Applications: ELISA, FA, FACS, Kinetics
• Reactivity: Human

Key Properties

• Clonality: Monoclonal
• Isotype: IgG
• Target: FOLR1
• Molecular Weight: 145.2 kDa
• Purity: > 95%
• Endotoxin: < 1 EU/mg
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 100 mM Pro-Ac 20 mM Arg pH 5.0
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Anti-FOLR1 / FRA Reference Antibody (mirvetuximab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

The purity of Anti-FOLR1 / FRA Reference Antibody (mirvetuximab)is more than 100% ;determined by SEC-HPLC.

Immobilized human FRa His at 2 μg/mL can bind Anti-FOLR1 / FRA Reference Antibody (mirvetuximab);EC50=0.01123μg/mL.

SKOV3 cells were stained with Anti-FOLR1 / FRA Reference Antibody (mirvetuximab) and negative control protein respectively; washed and then followed by PE and analyzed with FACS; EC168=0.03238 ug/mL.

The endocytosis ratio mirvetuximab by Human Frα HEK 293 increased with the increase of antibody concentration; and the Internalization Rate (%) 75% at antibody concentration of 55 ng/mL.

Quick Database Links

Gene Symbol

FOLR1