Anti-Hu CD266 APC

SKU: orb2321158

Description

CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.

Images & Validation

• Tested Applications: FC
• Reactivity: Human, Mouse
• Application Notes:
  Flow cytometry: Recommended dilution: 5-15 μg/ml. Extracellular and intracellular staining.

Key Properties

• Clonality: Monoclonal
• Isotype: Mouse IgG2b
• Clone No.: ITEM-4
• Immunogen: human CD266-transfected P815 cells
• Target: CD266
• Conjugation: APC

Storage & Handling

• Storage: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
• Buffer/Preservatives: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Concentration: 0.1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TWEAKR, FN14, TNFRSF12A

Quick Database Links

Gene Symbol

CD266

UniProt

Q9NP84

NCBI Gene ID

51330