Anti-Hu SIGLEC10 Purified

SKU: orb1729633

Description

SIGLEC10 is a CD33-related receptor of sialoglycans, expressed on eosinophils, monocytes, a subpopulation of NK cells, and at lower level on B cells. Its murine ortholog is Siglec G. SIGLEC10 seems to act as an immunomodulatory receptor, which binds to VAP-1, a glycoprotein expressed on endothelium under inflammatory conditions. Another ligand of SIGLEC10 is CD24, a marker of poorer prognosis in carcinomas.

Images & Validation

• Tested Applications: ELISA, IHC, IP
• Reactivity: Human

Key Properties

• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone No.: 5G6
• Immunogen: SIGLEC10 extracellular domain fused with human IgG1 Fc fragment
• Target: SIGLEC10
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PRO940, SGL2

ELISA analysis of human SIGLEC 10-Fc fusion protein (5 μg/ml) using mouse monoclonal antibody 5G6 (0.016 - 10 μg/ml).

Quick Database Links

Gene Symbol

SIGLEC10

UniProt

Q96LC7

NCBI Gene ID

89790