Anti-PPM1D Purified

SKU: orb1467381

Description

PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent, and subsequently PPM1D negatively regulates the p53-mediated transcription, thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas, and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer.

Research Area

Product Categories/Research Tools,Product Categories/Research Area,Epigenetics

Images & Validation

• Tested Applications: ELISA, FC, ICC, IHC-P, WB
• Dilution Range: Western blotting: Recommended dilution: 1-2 μg/ml. Flow cytometry: Recommended dilution: 1-5 μg/ml. Intracellular staining.
• Reactivity: Human, Mouse
• Application Notes:
  Western blotting: Recommended dilution: 1-2 μg/ml.

Key Properties

• Antibody Type: Primary Antibody
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone No.: 7E11/C5
• Immunogen: Purified human PPM1D
• Target: PPM1D
• Purity: Purified by protein-A affinity chromatography.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Hazard Information: Non-Toxic
• Disclaimer: For research use only

Alternative Names

WIP1, Protein phosphatase 1D, JDVS, WIP1, IDDGIP

Quick Database Links

Gene Symbol

PPM1D

UniProt

O15297

NCBI Gene ID

8493