Anti-TSLP Reference Antibody (tezepelumab)

SKU: orb1805495

Description

Anti-TSLP Reference Antibody is expressed from CHO. The heavy chain type is huIgG2, and the light chain type is hulambda. It has a predicted MW of 145.5 kDa.

Images & Validation

• Tested Applications: ELISA, FA, FACS, Kinetics
• Reactivity: Human

Key Properties

• Clonality: Monoclonal
• Isotype: IgG
• Target: TSLP
• Molecular Weight: 145.5 kDa
• Purity: > 95%
• Endotoxin: < 1 EU/mg
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 100 mM Pro-Ac 20 mM Arg pH 5.0
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Anti-TSLP Reference Antibody (tezepelumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

The purity of Anti-TSLP Reference Antibody (tezepelumab)is more than 98.64% ;determined by SEC-HPLC.

Immobilized human TSLP His at 2 μg/mL can bind Anti-TSLP Reference Antibody (tezepelumab);EC50=0.0518μg/mL.

Anti-TSLP Reference Antibody (tezepelumab)-induced FACS Blocking activity was evaluated using TSLPR/IL7R-CHO-K. The IC50 was approximately 0.0802 μg/mL.

Tezepelumab reduced levels of IL13 in BALF of OVA asthma model on B-hTSLP/hTSLPR mice. The result showed significant IL13 inhibition effects at 15 mpk.

Quick Database Links

Gene Symbol

TSLP