ASK1-IN-1

SKU: orb1297940

Description

ASK1-IN-1

Research Area

Product Categories/Products/Small Molecules,Apoptosis

Key Properties

• CAS Number: 2411382-24-4
• MW: 405.41
• Purity: 98%
• Formula: C₁₉H₁₉N₉O₂
• SMILES: CC(C)n1c(-c2cccc(NC(c3cn(-c4nccnc4)nc3OC)=O)n2)nnc1

Bioactivity

• Target IC50:
  ASK1:138 nM(cell)|ASK1:21 nM(Biochemical)
• In Vivo:
  ASK1-IN-1 shows low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC50/IC70/IC90 at trough in the brain for 12 hours of 50/115/435 mg/kg respectively.
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• In Vitro:
  ASK1-IN-1 shows good potency with cell IC50 of 138 nM. ASK1-IN-1 has superior CYP inhibition profile.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146027049