Aslan003

SKU: orb746502

Description

ASLAN003 is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [1035688-66-4]
• MW: 356.322871685028
• Formula: C₁₉H₁₄F₂N₂O₃
• SMILES: FC1C([H])=C(C([H])=C(C=1N([H])C1=C(C(=O)O[H])C([H])=C([H])C([H])=N1)F)C1C([H])=C([H])C([H])=C(C=1[H])OC([H])([H])[H]

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only