Ataxin 1 Antibody: APC

SKU: orb151100

Description

Mouse monoclonal to Ataxin 1 (APC). Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons..

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Neuroscience,Epigenetics,Neuroscience | Neurodegeneration | Cell Signaling | Epigenetics and Nuclear Signaling

Images & Validation

• Tested Applications: ICC, IF, IHC
• Dilution Range: WB (1:1000)
• Reactivity: Human, Mouse, Rat
• Application Notes:
  1 µg/ml of SMC-475 was sufficient for detection of Ataxin 1 in 20 µg of COS cells transiently transfected with Ataxin-1 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone No.: N65/37 (Formerly sold as S65-37)
• Immunogen: Synthetic peptide amino acids 746-761 (RKRRWSAPETRKLEKS) of mouse ataxin-1. Rat: 93% identity (15/16 amino acids identical). Human: 87% identity (14/16 amino acids identical).
• Target: Ataxin 1
• Molecular Weight: 85kDa
• Conjugation: APC

Storage & Handling

• Storage: Conjugated antibodies should be stored according to the product label
• Buffer/Preservatives: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ataxin-1 antibody, ATX1 antibody, Atxn1 antibody, D6S504E antibody, OTTHUMP00000016065 antibody, SCA1 antibody, Spinocerebellar ataxia type 1 protein antibody, Spinocerebellar ataxia type 1 protein homolog antibody

Quick Database Links

Gene Symbol

Ataxin 1

UniProt

P54254

NCBI Gene ID

20238

RefSeq (Protein):NP_001186233.1