AZD-3463

SKU: orb1306938

Description

AZD-3463

Research Area

Product Categories/Products/Small Molecules,Autophagy|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Apoptosis

Key Properties

• CAS Number: 1356962-20-3
• MW: 448.95
• Purity: 99.13%
• Formula: C₂₄H₂₅ClN₆O
• SMILES: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12)N1CCC(N)CC1

Bioactivity

• Target IC50:
  ALK:0.75 nM(Ki)
• In Vivo:
  In various in vitro models resistant to Crizotinib, AZD3463 exhibits antiproliferative efficacy against five out of six cell lines, with a potency four times greater than that of the parent H3122 cells. AZD3463 is effective across tumor cell lines with ALK fusion, including DEL (ALCL NPM-ALK), H2228 (NSCLC EML4-ALK), and H3122 (NSCLC EML4-ALK), by inhibiting ALK and reducing its autophosphorylation.
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• In Vitro:
  In vivo, AZD-3463 is equally effective against both the mutated L1196M and the wild-type ALK. When acting on transplanted tumors in vivo, AZD-3463 dose-dependently inhibits pALK, leading to the stagnation (H3122) or reduction (DEL, H2228) of tumor volume.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

56599293