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AZD1981

SKU: orb1300801

Description

AZD1981

Research Area

Product Categories/Products/Small Molecules,Endocrinology/Hormones|||Immunology/Inflammation|||GPCR/G Protein

Images & Validation

Key Properties

CAS Number802904-66-1
MW388.87
Purity99.54%
FormulaC19H17ClN2O3S
SMILESCC(=O)Nc1cccc2n(CC(O)=O)c(C)c(Sc3ccc(Cl)cc3)c12

Bioactivity

Target IC50
CRTh2 (DP2) receptor:4 nM
In Vivo
AZD1981 has high oral bioavailability in male sprague dawley rats. In guinea pig hind limb model, AZD1981 (100 nM) completely inhibits DK-PGD2-induced eosinophil mobilization.
In Vitro
AZD1981, as a potent antagonist in a disease relevant cell system, inhibits DK-PGD2-induced CD11b expression in human eosinophils with IC50 of 10 nM. AZD1981 blocks DP2-mediated shape change in human eosinophils and basophils in blood, as well as DP2-mediated chemotaxis of human Th2 cells and eosinophils. Moreover, AZD1981 also blocks the binding of [3H]PGD2 to mouse, rat, guinea pig, rabbit and dog recombinant DP2.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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AZD1981 (orb1300801)

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% DMSO +
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Available Sizes

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1 ml x 10 mm (in DMSO)
$ 130.00
10 mg
$ 150.00
25 mg
$ 200.00
50 mg
$ 300.00
100 mg
$ 390.00
200 mg
$ 530.00
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