BCOR Antibody / BCL-6 corepressor

SKU: orb1822606

Description

Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin s lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

Images & Validation

• Tested Applications: IHC-P
• Dilution Range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG1, kappa
• Clone No.: BCOR/2372
• Immunogen: A recombinant partial protein sequence (within amino acids 100-400) from the human protein was used as the immunogen for the BCL-6 corepressor antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the BCL-6°Corepressor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This BCL-6 corepressor antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

UniProt

Q6W2J9