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Description
Research Area
,Recombinant-Protein
Images & Validation
−
Key Properties
−| Expression System | E. coli |
|---|---|
| Biological Origin | Human |
| Biological Activity | Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11). |
| Tag | C-6xHis |
| Expression Region | Gly2-Pro505 |
| MW | 50-65 KDa (reducing condition) |
| Purity | 98.00% |
| Protein Sequence | Gly2-Pro505 |
Storage & Handling
−| Storage | -20°C |
|---|---|
| Expiration Date | 6 months from date of receipt. |
| Disclaimer | For research use only |
Similar Products
−Recombinant Human BLK Protein, His Tag [orb1552835]
≥90% as determined by SDS-PAGE
This protein contains the human BLK(Gly2-Pro505) was fused with the C-terminal His Tag and expressed in E. coli.
100 μg, 50 μg
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Protocol Information
Protein Handling and Storage Guide
Protein Handling Guide
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