Bosutinib hydrate

SKU: orb1686162

Description

Bosutinib hydrate

Research Area

Product Categories/Products/Small Molecules,Cytoskeletal Signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

Key Properties

• CAS Number: 918639-08-4
• MW: 548.46
• Purity: 99.87%
• Formula: C₂₆H₃₁Cl₂N₅O₄
• SMILES: O.COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl

Bioactivity

• Target IC50:
  Abl:2.4 nmol/L|Csk:314 nmol/L
• In Vivo:
  Administration of Bosutinib hydrate(SKI-606) at doses of 75 mg/kg twice daily or 150 mg/kg once daily can promote complete regression of human K562 xenografts for up to 40 days.
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• In Vitro:
  Bosutinib hydrate(SKI-606)was a inhibitor of two Src-related kinases (i.e., Fgr and Lyn with IC50s of 0.174 and 0.850 nmol/L, respectively).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11990828