BRD4/CK2-IN-1

SKU: orb1473191

Description

BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC)[1]

Research Area

Product Categories/Products/Small Molecules

Key Properties

• CAS Number: [2756851-99-5]
• MW: 564.03
• Formula: C₂₉H₃₀ClN₅O₅
• SMILES: O=C1C2=C(OC)C=C(OC)C=C2N=C(C3=CC=C(OCC(NC4=CC(Cl)=C(N5CCN(C)CC5)C=C4)=O)C=C3)N1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only