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Cabozantinib
SKU: orb1305297
Description
Research Area
Product Categories/Products/Small Molecules,Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors
Images & Validation
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Key Properties
−| CAS Number | 849217-68-1 |
|---|---|
| MW | 501.51 |
| Purity | 99.88% |
| Formula | C28H24FN3O5 |
| SMILES | O=C(NC1=CC=C(F)C=C1)C2(C(=O)NC3=CC=C(OC=4C=CN=C5C=C(OC)C(OC)=CC54)C=C3)CC2 |
Customer Validated Data
− The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.
Success by Application
Reactivity Distribution
Latest Experiments
4 ResultsDilution
Sample
Summary
In vitro
Mouse
1, 3, and 10 μM/ 1.3 μM
Primary HCC cells (2D) and 3D tumoroids (tHCC16–tHCC23).
Cabozantinib was used as a receptor...
In vitro, In vivo
Human
In vitro: 1, 3, and 10 μM. In vivo: 10 mg/kg.
Human HCC cell lines, patient-derived HCC tumoroids, liver organoids (controls), and spontaneous mouse HCC tumors
Cabozantinib was used as a receptor...
In vitro
Human
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Human HCC cell lines SNU449, SNU449-Axl⁻ (Axl-knockout), HLF, and Huh7.
Cabozantinib was used as a tyrosine...
In vitro
Human
0.1–25 μM, 12 μM,
Human clear cell RCC cell lines: 786-O (WT and sunitinib-resistant 786-O/S) and Caki-2 (WT and sunitinib-resistant Caki-2/S).
Cabozantinib was used to evaluate its...
Storage & Handling
−| Storage | -20°C |
|---|---|
| Expiration Date | 12 months from date of receipt. |
| Disclaimer | For research use only |
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Compound Identifiers
PubChem CID
Key Properties
− No computed properties available.
Protocol Information
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