Caspase 3 (Cleaved-Asp175) Antibody

SKU: orb126608

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Description

Rabbit polyclonal antibody to caspase 3 is also known as apopain whose expression can be detected in the tonsils and skeletal muscles but is highly expressive in the spleen and kidney. It is found in the death-inducing signaling complex in the plasma membrane. This protein is extensively involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. It cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain.

Research Area

Product Categories/Products/Antibodies/Primary Antibodies,Neuroscience,Signaling Pathways,Cancer,Product Categories/Antibodies,Product Categories/Products/Antibodies,Epigenetics,Signaling Pathways/Apoptotic

Images & Validation

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Tested Applications	IHC, WB
Dilution Range	WB: 1:500-3000, IHC-P: 1:50-100, ELISA: 1:20000
Reactivity	Human, Mouse, Rat

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	Internal
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Concentration	1mg/ml
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anti-Apopain antibody, anti-CASP 3 antibody, anti-CASP-3 antibody, anti-CASP3 antibody, anti-CC3 antibody, anti-CPP 32 antibody, anti-CPP-32 antibody, anti-CPP32 antibody, anti-CPP32B antibody, anti-ICE3 antibody, anti-LICE antibody, anti-PARP cleavage protease antibody, anti-Procaspase3 antibody, anti-Protein Yama antibody, anti-Yama antibody, anti-Yama protein antibody, anti-Caspase-3 antibody, anti-Caspase3 antibody, anti-caspase3 antibody, anti-caspase 3 antibody

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