Cav3.2 Antibody: Biotin

SKU: orb148212

Description

Mouse monoclonal to CaV3 (Biotin). 2. Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand-gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, CaV3. 2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy. Studies also suggest that the up-regulations of CaV3. 2 may participate in the progression of prostate cancer toward an androgen-independent stage. ...

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Neuroscience,Epigenetics,Neuroscience | Ion Channels | Calcium Channels | Voltage-Gated Calcium Channels | Cancer | Cell Signaling

Images & Validation

• Tested Applications: ELISA, ICC, IF, IHC, WB
• Dilution Range: WB (1:1000), IHC (1:1000), ICC/IF (1:100)
• Reactivity: Human, Mouse, Rat
• Application Notes:
  1 µg/ml of SMC-303 was sufficient for detection of Cav3.2 in 10 µg of HEK cell lysate expressing Cav3.2 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone No.: N55/10 (Formerly sold as S55-10)
• Immunogen: Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2
• Target: Cav3.2
• Molecular Weight: 260kDa
• Conjugation: Biotin

Storage & Handling

• Storage: Conjugated antibodies should be stored according to the product label
• Buffer/Preservatives: 136.36mM Ethanolamine, and 9.55mM Sodium Bicarbonate in 95.45% PBS
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cav3.2 antibody, CACNA1H antibody, CACNA1HB antibody, calcium channel antibody, voltage-dependent antibody, T type antibody, alpha 1H subunit antibody, calcium channel antibody, voltage-dependent antibody, T type antibody, alpha 1Hb subunit antibody, ECA6 antibody, EIG6 antibody, FLJ90484 antibody, Low-voltage-activated calcium channel alpha1 3.2 subunit antibody, low-voltage-activated calcium channel alpha13.2 subunit antibody, voltage dependent t-type calcium channel alpha-1H subunit antibody, voltage-dependent T-type calcium channel subunit alpha-1H antibody, voltage-gated calcium channel alpha subunit Cav3.2 antibody, voltage-gated calcium channel alpha subunit CavT.2 antibody, Voltage-gated calcium channel subunit alpha Cav3.2 antibody

Quick Database Links

Gene Symbol

Cav3.2

UniProt

O95180

NCBI Gene ID

8912

RefSeq (Protein):NP_001005407.1