CD45RA Antibody (Leukocyte marker)

SKU: orb1824323

Description

CD45 is a family of single chain transmembrane glycoproteins, consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are rod shaped, heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1q31-32.CD45 is exclusively expressed in haematolymphoid cells. Almost all haematolymphoid cells, including precursor cells and mature B- and T-lymphocytes, granulocytes, monocytes/histiocytes and interdigitating reticulum cells and follicular dendritic cells express CD45. This protein is detected in the large majority of haematolymphoid neoplasms, i.e., leukemias and malignant lymphomas. Overall, about 90% of malignant lymphomas are CD45 positive.CD45 is an important marker in the primary tumor screening panel in order to identify haematolymphoid differentiation. Loss of CD45 in precursor B-cell neoplasms is a negative prognostic parameter.

Images & Validation

• Tested Applications: IHC-P
• Dilution Range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Recombinant
• Isotype: Rabbit IgG, kappa
• Clone No.: PTPRC/4367R
• Immunogen: A recombinant partial protein sequence (within amino acids 1-600) from the human protein was used as the immunogen for the CD45RA antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the CD45RA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This CD45RA antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

UniProt

P08575