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Celastrol

SKU: orb1225253

Description

Celastrol (Tripterin), a bioactive compound from Thunder God Vine, is a potent proteasome inhibitor that preferentially targets the 20S chymotrypsin-like activity (IC₅₀ = 2.5 µM) and inhibits the 26S proteasome in prostate cancer cells. It induces apoptosis, promotes accumulation of ubiquitinated proteins and proteasome substrates, suppresses AR expression, and demonstrates significant tumor growth inhibition in vivo.

Images & Validation

Key Properties

CAS Number34157-83-0
MW450.6
Purity>98% (HPLC)
FormulaC29H38O4
SMILESCC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
Target20Sproteasome
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

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200 mg
500 mg
5 mg
$ 90.00
10 mg
$ 120.00
25 mg
$ 170.00
50 mg
$ 210.00
100 mg
$ 260.00