CNX-774

SKU: orb181026

Description

CNX-774 is a potent, selective, and orally available small molecule inhibitor of Btk (IC50< 1 nM) that forms a ligand-directed covalent bond with Cys-481, a non-conserved amino acid within the active site of the enzyme.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [1202759-32-7]
• MW: 499.49638
• Formula: C₂₆H₂₂N₇O₃F
• SMILES: O=C(NC)C1=NC=CC(OC2=CC=C(NC3=NC=C(F)C(NC4=CC=CC(NC(C=C)=O)=C4)=N3)C=C2)=C1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Chemical structure of CNX-774