COVID-19 Spike Protein (Alpha Variant) mRNA-LNP

SKU: orb2719994

Description

This product utilizes the lipid nanoparticle (LNP) technology platform for The spike protein of COVID-19 is a glycoprotein that helps the virus attach to various surfaces in the built environment, increasing the potential for virus transmission. The best-known vaccines we use are the spike protein vaccines delivered via mRNA. While the role of vaccination in controlling outbreaks is undeniable, the recurring emergence of new variants of Covid-19, such as the Delta and Omega variants, poses new challenges, particularly their rapid global spread. This product is designed as a tool for the delivery and expression of full-length spike protein mRNA of COVID-19 Strain Alpha for vaccine research. This product utilizes the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of the Alpha variant spike protein (COVID-19) mRNA to a variety of mammalian cells in vitro and in vivo. The LNP’s used are formulated with, SM-102, DSPC, cholesterol, and DMG-PEG2000 at optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. Alpha Spike protein consists of 1273 amino acids and its GenPept accession number is YP_009724390.

Images & Validation

• Application Notes:
  Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container. It is important not to spin for too long as this may rupture mRNA-LNPs. Do not vortex. Work with mRNA-LNPs on ice. It is important to minimize the time that the product spends at room temperature. After handling the product during experiments, return immediately to ice. mRNA-LNP products should only be handled with certified RNase-free reagents and consumables. Use of filtered pipette tips is highly recommended.

  Read more...

Storage & Handling

• Storage: 4°C; ice
• Form/Appearance: mRNA-LNPs suspended in PBS (-Ca, -Mg) (pH: 7.0-7.4).
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only