CUL2 (N) Antibody, Rabbit Polyclonal

SKU: orb67162

Description

Rabbit polyclonal to CUL2.Cullin-2 (CUL2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCSboxprotein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins.CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioningof the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of thecomplex is dependent on the neddylation of the cullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. ECS(VHL) mediates the ubiquitination of hypoxiainduciblefactor (HIF).

Research Area

Epigenetics,Product Categories/Products/Antibodies,Infectious Diseases,Product Categories/Products/Antibodies/Primary Antibodies

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human CUL2
• Molecular Weight: 87
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-CUL2 antibody,anti-Cullin2 antibody,anti-CUL2 antibody

Quick Database Links

UniProt

Q13617