CUL3 (C) Antibody, Rabbit Polyclonal

SKU: orb66953

Description

Rabbit polyclonal to CUL3.CUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division. CUL3 is a corecomponent of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligasecomplexes which mediate the ubiquitination and subsequent proteasomal degradation of targetproteins. As a scaffold protein, CUL3 may contribute to catalysis through positioning of the substrateand the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex isdependent on the neddylation of the cullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1 (By similarity). BCR(SPOP) is involved inubiquitination of BMI1/PCGF4, H2AFY and DAXX, and probably GLI2 or GLI3, as well as cyclin E andof cyclin D1.

Research Area

Product Categories/Products/Antibodies,Epigenetics,Product Categories/Products/Antibodies/Primary Antibodies

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human CUL3
• Molecular Weight: 89
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-CUL3 antibody,anti-Cullin3 antibody,anti-KIAA0617 antibody

Quick Database Links

UniProt

Q13618