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DAPT

SKU: orb181230

Description

DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Images & Validation

Key Properties

CAS Number[208255-80-5]
MW432.4604
FormulaC23H26F2N2O4
SMILESFC1C([H])=C(C([H])=C(C=1[H])C([H])([H])C(N([H])[C@@]([H])(C([H])([H])[H])C(N([H])[C@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)=O)F

Storage & Handling

Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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DAPT

Chemical structure of DAPT

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Protocol Information

DAPT (orb181230)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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1 ml x 10 mm (in DMSO)
$ 300.00
100 mg
$ 430.00
250 mg
$ 750.00
1 g
$ 1,410.00
DispatchUsually dispatched within 5-10 working days
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