Darunavir Ethanolate

SKU: orb1304312

Description

Darunavir Ethanolate

Research Area

Product Categories/Products/Small Molecules,Proteases/Proteasome|||Microbiology/Virology

Key Properties

• CAS Number: 635728-49-3
• MW: 593.74
• Purity: 99.68%
• Formula: C₂₉H₄₃N₃O₈S
• SMILES: CCO.[H][C@@]12CCO[C@]1([H])OC[C@@H]2OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN(CC(C)C)S(=O)(=O)c1ccc(N)cc1

Bioactivity

• Target IC50:
  HIV-1 protease:1 nM (Ki)
• In Vivo:
  Darunavir effectively combats both wild-type and protease inhibitor (PI)-resistant HIV strains, boasting an oral bioavailability of 37%. Its efficacy is significantly enhanced when used in conjunction with ritonavir, which raises its bioavailability to 82%.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

23725083