DHODH-IN-11

SKU: orb1309766

Description

DHODH-IN-11

Research Area

Product Categories/Products/Small Molecules,Metabolism|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

Key Properties

• CAS Number: 1263303-95-2
• MW: 265.27
• Purity: 98.14%
• Formula: C₁₅H₁₁N₃O₂
• SMILES: O\N=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1

Bioactivity

• Target IC50:
  DHODH:5.03(pKa)
• In Vitro:
  A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

51031365